Showing posts with label Hepatitis B vaccination. Show all posts
Showing posts with label Hepatitis B vaccination. Show all posts

Thursday, September 19, 2013

Vaccination can give birth to the end of hepatitis B

People may not realize that an infected mother can pass on the hepatitis B virus to her newborn. This is a serious disease caused by a virus that attacks the liver. According to the Centers for Disease Control and Prevention (CDC), the hepatitis B virus can cause lifelong infection, cirrhosis (scarring) of the liver, liver cancer, liver failure, and death. 

Fortunately, there’s a way to prevent transmission of the virus to newborns - vaccination at birth to prevent the perinatal transmission. Experts agree that the disease could even be eliminated by vaccinating all newborns. 

Recently, a small nonprofit called the Immunization Action Coalition (IAC) has been urging the nation’s birthing institutions to “Give birth to the end of hepatitis B,” asking them to get involved in promoting this standard of care and assuring administration of the hepatitis B vaccine shortly after birth. One way to assure the vaccine is given to newborns is for the hospital to make the vaccine birth dose part of a standard order set so it is universally administered before hospital discharge. Then, follow up in the doctor’s office or clinic with a total of 3 or 4 doses at properly spaced intervals would help more than 95% of infants, children, and adolescents develop lifelong immunity to the hepatitis B virus. It’s important for mothers to know about this and insist that their babies receive hepatitis B vaccine before they leave the hospital. If the mother is known to have the disease or her status is unknown, the vaccine should be given within 12 hours.

Despite the expert consensus, nearly one in three US newborns leaves the hospital un-vaccinated against hepatitis B, and approximately 800 US newborns become chronically infected each year because of perinatal exposure. Some doctors may decide not to give the baby the vaccine if the mother has a negative screening test, electing instead to give the vaccine after discharge. But this is risky. There can be situations where a medical error occurs, like ordering the wrong hepatitis B screening test or misinterpreting or mistranscribing hepatitis B test results. Failure to properly communicate test results to or within the hospital is also a possibility. There are also doctors who don’t notice that the mother was never tested and let it go, never getting the screening test for mom. So there is room for error - all reasons to give the vaccine at birth and the sooner the better. The hepatitis B vaccine for newborns is recommended by many professional organizations and health care agencies including the American Academy of Pediatrics and the CDC.

Wednesday, September 4, 2013

Hepatitis B Vaccination in Taiwan Cuts Deaths From Liver Disease, Cancer

Hepatitis B virus (HBV) infection causes infant fulminant hepatitis (IFH), and chronic HBV infection may progress to chronic liver disease (CLD) and hepatocellular carcinoma (HCC) or liver cancer. Taiwan launched a nationwide HBV immunization program for newborns in July 1984, which has successfully lowered the prevalence of chronic HBV carriers, incidence of HCC, and mortality of IFH in vaccinated birth cohorts.

From July 1984 to June 1986, the immunization program covered only newborns with high-risk mothers who were seropositive for HBV surface antigen. Coverage was extended to all newborns in July 1986, preschool children in July 1987, and primary school children in 1988-1990. Recombinant HBV vaccines replaced plasma-derived vaccines in 1992. The immunization coverage rates for birth cohorts from 1984 to 2010 was 88.8 percent to 96.9 percent. The mortality of IFH, CLD, and HCC and the incidence of HCC were compared among birth cohorts born before and after the launch of the program.

The researchers found that from 1977-1980 to 2001-2004, the age- and sex-adjusted rate ratios for individuals 5 to 29 years of age decreased by more than 90 percent for CLD and HCC mortality and by more than 80 percent for HCC incidence, which were higher than the previously reported reduction (70 percent) in HCC incidence for youth 6 to 19 years of age.

The mortality of IFH in vaccinated birth cohorts decreased by more than 90 percent from 1977-1980 to 2009-2011, which was greater than the previously reported reduction (approximately 70 percent) from 1975-1984 to 1985-1998. This long-term, high-coverage immunization program was associated with lower IFH mortality through increasing individual and herd immunity of vaccinated cohorts.