A groundbreaking study of nearly 2,300 extremely obese diabetes patients has identified genes associated with unhealthy liver function.
This is believed to be one of the first large-scale genome-wide association study in overweight patients with diabetes.Results of the study will be presented at the 64th annual meeting of the American Association for the Study of Liver Diseases Nov. 1-5 in Washington, D.C.
The study -- Genome-wide analysis identifies loci associated with total bilirubin levels, steatosis, and mild fibrosis in nonalcoholic fatty liver disease -- looked at how genomic factors affect the development of non-alcoholic fatty liver disease. It was selected for presentation from among a record 3,139 submittals from around the world proposed for what also is known as The Liver Meeting 2013.
These genetic factors could help us identify patients who are most at risk of developing non-alcoholic forms of fatty-liver disease (NAFLD), and which patients may be more likely to progress to severe forms of NAFLD, such as steatohepatitis (NASH). NAFLD is the build up of extra fat in liver cells, not caused by alcohol. It is one of the most common causes of chronic liver disease. NASH is liver inflammation and damage caused by a buildup of fat in the liver, not caused by alcohol. The researchers discovered genes that may help identify those patients most at risk for the types of liver disease so severe that they could require transplants.
This is believed to be one of the first large-scale genome-wide association study in overweight patients with diabetes.Results of the study will be presented at the 64th annual meeting of the American Association for the Study of Liver Diseases Nov. 1-5 in Washington, D.C.
The study -- Genome-wide analysis identifies loci associated with total bilirubin levels, steatosis, and mild fibrosis in nonalcoholic fatty liver disease -- looked at how genomic factors affect the development of non-alcoholic fatty liver disease. It was selected for presentation from among a record 3,139 submittals from around the world proposed for what also is known as The Liver Meeting 2013.
These genetic factors could help us identify patients who are most at risk of developing non-alcoholic forms of fatty-liver disease (NAFLD), and which patients may be more likely to progress to severe forms of NAFLD, such as steatohepatitis (NASH). NAFLD is the build up of extra fat in liver cells, not caused by alcohol. It is one of the most common causes of chronic liver disease. NASH is liver inflammation and damage caused by a buildup of fat in the liver, not caused by alcohol. The researchers discovered genes that may help identify those patients most at risk for the types of liver disease so severe that they could require transplants.
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